Researches find that the absorption of some toxic substance will inhibit the activity of some enzymes and affect the regeneration and synthesis of melanophore, causing the direct damage to melanin. From the morbidity around the world, we can see that environment and food pollution have great close relationship with the onset of this disease. The countries with high population density and in development have higher morbidity, and India is in the first place, and China and Japan are the next. Western developed countries have lower morbidity. In our country, the heavy industry cities and oildom and coastal region have a higher morbidity. Here are some main causes of vitiligo as following:
First, the internal secretion and immunity function disorder: Some pathogenic factors ( chemistry substance and metal toxic substance ) will lead to body immunity function disorder, internal secretion imbalance. Then generate melanin cell antibodies and cause melanin cell damage and attrition. The damaged melanophore can release antigen and stimulate human body to produce more melanin cell antibodies, which will make more melanophore be damaged. This phenomenon will cause a vicious circle and aggravate the vitiligo condition. Human immunity response reaction is a complicated physiological process. Besides, long-term mental pressure and psychological trauma will also lead to neurohumoral regulation imbalance and internal secretion disorder then arouse vitiligo.
Second, the deficiency of trace elements: Trace elements are very necessary activity substance participating in the body metabolism, such as copper, zinc, selenium and iodine. They can directly take part in the melanophore synthesis and protect the melanophore from the damage of heavy mental toxic. Researches find that the deficiency of trace elements and imbalance proportion will both lead to melanophore synthesis obstacle.
Third, inheritance factors: After clinical observation, only few cases are related to inheritance, but it is still an important factor for vitiligo patients. It can not affect the treatment for vitiligo.
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