Vitiligo occurs when melanin-forming cells (melanocytes) die or stop producing melanin — the pigment that gives your skin, hair and eyes color. The involved patches of skin become lighter or white. Etiology of the disease remains unclear. Recent research considers the following factors. Here are some causes of the vitiligo disease. The cause is various for vitiligo disease. Doctors don't know why the cells fail or die. It may be related to:
The vitiligo may occur in the twin or the family, it means the heredity play a very important in vitiligo. Study shows that the Vitiligo with incomplete penetrance, genes has multiple disease-causing loci.
2. Autoimmunity theory
The vitiligo may combine the autoimmune disease, such as thyroid disease, diabetes, chronic adrenal function declined. Malignant anemia, rheumatic arthritis, malignant melanoma etc. we also can detect the specific antibodies from serum of multiple organs. Such as anti-thyroid antibodies, anti-parietal cell antibody, anti adrenal antibodies, anti-parathyroid gland antibodies, ant smooth muscle antibodies, anti-melanocyte antibody.
3. Neurochemical theory
Mental factors are close related to the morbidity of vitiligo. Most of the vitiligo patient in the beginning of the vitiligo and the developing period, they were experiencing the psychological trauma, or excessive tension, depression or frustration. Nerve endings of the white spot have degenerated, this also support nerve chemistry theory.
4. Melanocyte self- destructed theory.
Vitiligo patient can produce antibodies and T lymphocytes. It indicates that may lead to obstruction of melanocytes. Cells itself can synthesis some poisonous melanin precursor substance, and chemicals that cause the skin discoloration, all these substance will damage the melancytes.
5. Microelement deficiency theory
The Copper or copper blue protein level decreased in the blood and skin for the vitiligo patient, it cause the tyrosinase activity reduce, therefore the metabolic rate of melanin will be effected.
6. Other factors
Trauma, exposure to sun and some photosensitive drugs will induce vitiligo.
These six factors may cause the vitiligo, when you find any abnormal of your skin, please see doctor as fast as you can, because the white spot may spread very fast.