Psoralens are materials that make the skin more sensitive to UV light. They are called photosensitizing agents and they found in plants or manufactured artificially. The psoralen can use to help vitiligo recover. How does the psoralen help the vitiligo to recover?
Vitiligo is a skin disorder that causes the skin to lose its color. The condition occurs when melanocytes the skin cells that produce melanin, the chemical that gives skin its color or pigmentation are destroyed by the body’s immune system.Vitiligo usually begins with a few small white patches that may gradually spread over the body over the course of several months. Vitiligo can develop on any part of the body, including the mucous membranes (moist lining of the mouth, nose, genital, and rectal areas), the eyes, and inner ears, but typically begins on the hands, forearms, feet, and face. so we use the psoralen to help treat the vitiligo. How we use this medicine, and how it helps vitiligo to recover?For those adults have a generalized lesion, we usually take the protopic by orally, and we use the long wave to irradiate after intake this medication. For those children and adults patients when the skin lesions is less. We can apply some medication on the local skin then use the long wave UV to irradiate the skin to make the skin turn to red.
When the vitiligo recoded gradually, the epidermis will have some new melancytes, the amount of non-function melancytes more than vitiligo in normal condition at the internal root sheath of external follicle hair. The progress of the recovery will start from the follicle lower middle part. The medication will start to stimulate non function melancytes to split and multiply at the internal root sheath of external follicles. The melancytes will migrate along the superficial root sheath of external follicle hair to epidermis. During the migration, the melancytes’ function and form gradually become mature. The dopa response to the melancytes from weak to strong, the branches increasing and expanding after the melancytes reach the epidermis, the melancytes will spread to the surrounding from the centre of follicular orifice, this phenomenon called follicular pigment island in clinical.