Nowadays, the causes and pathogenesis of vitiligo are still not clear yet. There are many hypothesis to explain various clinical manifestation of different vitiligo patients. Why 308nm excimer laser therapy can treat vitiligo? Its therapy mechanism may be related to T lymphocyte apoptosis. Bian2chi and other people have researched by using immunohistochemical method that 308nm excimer laser can clean up the infiltrative T lymphocyte at lesion positions. Novak and others have researched that 308nm excimer laser can promote the activated T lymphocyte at vitiligo lesion positions apoptosis. The treatment effect is quite obvious, even more obvious than NB-UVB’s ability to cause apoptosis.
After 308 laser irradiation, it can lead to T lymphocyte apoptosis, thus making the vitiligo lesions disappear not only from naked eye levels, but also making the structures recover to be normal on micro level. Vitiligo is characteristic by selective melanophore, it may relate to patients’ autoimmune response. Narrow band ultraviolet( NB-UVB) may have immunomodulatory effects to make human cells and body fluid generate immunity, which can help to stabilize depigmentation progress. Besides, NB-UVB has been widely identified as similar as PUVA(psoralen photochemical therapy), which can stimulate remained melanophore to gather around peripheral hair follicle outer root sheath. Melanophore can go on mitosis, the generation and movement of melanin, always be induced by various cytokines and inflammatory mediator, including interleukin, tumor necrosis factor α, leukotriene C4. Recent researches indicate that after UVB irradiation, various cytokines and inflammatory mediator will increase, which indicates that this is on mechanism of UVB inducing the restore of melanin.
Someone ask about the cost of 308 excimer laser, in different hospitals, the charging standard has great differences. Generally speaking, it is calculated according to light spots. Each light spot is about 6-8 dollars per time. If your vitiligo area, hundreds of light spots needs quite much money. Therefore, pure laser therapy is a treatment costing lots of money. Therefore, you need doctors to make specific treatment plans for you according to your vitiligo condition.
If you want a further knowledge about vitiligo causes, you can send your own problem to firstname.lastname@example.org and we will give you a professional solution. After all, the symptoms are similar, but the real conditions are different.To cure this illness,we need to find the authentic pathogenesis according to different conditions of different patients.